In vitro cytotoxic activity of ethanolic extracts of Thevetia peruviana cells cultured in bioreactor
DOI:
https://doi.org/10.3407/rpn.v5i2.6857Keywords:
Thevetia peruviana, cell cultures, cardiotonics, cytotoxic activity, cell viabilityAbstract
Thevetia peruviana is an ornamental plant characterized by its high content of cardiotonic glycosides with ionotropic, anti-tumoral and cytotoxic activities.
References
. Arias J. (2013) Optimización de parámetros de cultivo en suspensión de células de la especie vegetal Thevetia peruviana y su efecto en la producción de metabolitos secundarios. 71p. Trabajo de grado (Magister en ciencias – Biotecnología). Universidad nacional de Colombia. Medellín. Facultad de ciencias.
. Arias J, Zapata K, Rojano B, Peñuela M, Arias M (2017) Cardiac glycosides, phenolic compounds and antioxidant activity from plant cell suspensión cultures of Thevetia peruviana. Rev. U.D.C.A Acrt. & Div. Cient.20(2): 353-362.
. Mendoza D, Arias J, Cuaspud O, Arias M. (2020). Phytochemical screening of callus and suspensions cultures of Thevetia peruviana. Brazilian Archives of Biology and Technology, 63, 1–14. https://doi.org/10.1590/1678-4324-2020180735
. Kaushik V, Azad N, Yakisich, J. et al. (2017) Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers. Cell Death Discov. 3, 17009. https://doi.org/10.1038/cddiscovery.2017.9
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